| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H53N9O7S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AT-1002, a 6-mer synthetic peptide[1], is a tight junction regulator and absorption enhancer[2]. It has the molecular formula C32H53N9O7S, MW 707.88.
Physical & Chemical Properties
| CAS Number | 835872-35-0 |
|---|---|
| Molecular Formula | C32H53N9O7S |
| Molecular Weight | 707.88 g/mol |
| SMILES | N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CS)C(N[C@@H]([C@H](CC)C)C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O |
| Signaling Pathway | Cytoskeleton |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
AT-1002 is a 6-mer synthetic peptide from an emerging novel class of compounds that reversibly enhance paracellular transport of molecules across the epithelial barrier. Cys-Cys dimerization can occur with AT-1002[1]. In undifferentiated Caco-2 cells treated with AT-1002 (0 to 5 mg/mL, 3 or 24 hours), viability is assessed through cellular ATP content. AT-1002 treatment for up to 3 h leaves cell viability unaffected at every concentration; notably, Caco-2 viability is not affected by 5 mg/mL AT-1002. After 24 h, AT-1002 reduces cell viability at concentrations of 2.5 mg/mL and higher. However, cells remain viable at 24 h if they are washed after 3 h of exposure to AT-1002, indicating that AT-1002 does not irreversibly damage cells[2].
Cell Viability Assay[2]
| Cell Line | Caco-2 cells |
|---|---|
| Concentration | 0 to 5 mg/mL |
| Incubation Time | 3 or 24 hours |
| Result | Treatment for up to 3 h did not affect cell viability at any concentration. Reduced cell viability after 24 h at concentrations of 2.5 mg/mL and higher. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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