| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H21Cl2N3 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
AT7867 hydrochloride is a potent, orally active inhibitor of AKT and p70 S6 kinase, with an anticancer effect[1]. It has a molecular formula of C20H21Cl2N3 and a molecular weight of 374.31 g/mol.
Physical & Chemical Properties
| CAS Number | 2624336-89-4 |
|---|---|
| Molecular Formula | C20H21Cl2N3 |
| Molecular Weight | 374.31 g/mol |
| SMILES | ClC1=CC=C(C=C1)C2(CCNCC2)C3=CC=C(C=C3)C4=CNN=C4.Cl |
| Signaling Pathway | PI3K/Akt/mTOR |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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Flavonoid Fisetin Alleviates Ovarian Aging of Laying Chickens by Enhancing Antioxidant Capacity and Glucose Metabolic Homeostasis. Antioxidants (Basel) 2024 Nov 21;13(12):1432. PMID: 39765761
The mTOR inhibitor manassantin B reveals a crucial role of mTORC2 signaling in Epstein-Barr virus reactivation. J Biol Chem 2020 May 22;295(21):7431-7441.
J Funct Foods. 55 (2019) 296-304.
Glucose Transport by Follicle-Stimulating Hormone Is Mediated Through the Akt/FOXO1 Pathway in Ovine Granulosa Cells. Vet Med Sci 2025 Mar;11(2):e70294. PMID: 40065595
Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML. Oncotarget 2016 May 17;7(20):29131-42.
