| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-azaniumyl-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoate.
- CAS number: 140158-50-5
- Molecular formula: C10H16N2O4.
- Purity: >96%
- Concentration: 0.5-50 µM.
- Form: Lyophilized Powder
- Solubility: Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: GluK1 (GluR5) kainate receptors
- Source: Synthetic
- Activity: ATPA is a potent and selective agonist of GluR5 kainate receptor (EC50 = 0.66 µM), inactive on GluR6 and less active on other kainate receptor subtypes. It is also a significantly weaker agonist of AMPA receptors (EC50 = 8 µM-62 µM, depending on subtype)1,2.
Scientific background
ATPA, an AMPA derivative, is a potent and selective agonist of the GluR5 (GluK1) kainate receptor subtype, with an EC50 value of 0.66 µM1. ATPA is less active towards other kainate receptor subtypes and is inactive towards GluR6. The compound also shows weak agonistic activities towards AMPA receptors1,2. Studies show that ATPA can induce clonic seizures when infused intravenously or directly into the rat amygdala3.GluR5 containing kainate receptors play an important role in the regulation of GABA(A) receptor-mediated inhibitory transmission in the hippocampus and in the amygdala3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
