Atromentin

SKU:BHB21902387
Overview
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Atromentin (CAS 519-67-5) is an enoyl-ACP reductase FabK inhibitor. Relevant to Anti-infection research. Molecular formula C18H12O6, molecular weight 324.29 g/mol. Of microbial origin (fungus F010248).
CAS Number 519-67-5
Molecular Weight 324.29 g/mol
Storage See Certificate of Analysis
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Catalog no. Size
HY-165368-50MG 50 mg
HY-165368-100MG 100 mg
HY-165368-250MG 250 mg
Available Options

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  • Options: Size: 50 mg, 100 mg, 250 mg
  • Lead time: confirmed on inquiry for every option.
  • Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
  • Shipping: Room temperature in continental US; may vary elsewhere.
  • Upon receipt: store as stated on the Certificate of Analysis; contact us if you need the condition before ordering.
Field Specification
CAS no. 519-67-5
Applications
  • Functional Assay (In Vitro)
Source Microbial — fungus F010248
Molecular weight 324.29
Molecular formula C18H12O6
SMILES O=C1C(O)=C(C(=O)C(O)=C1C=2C=CC(O)=CC2)C=3C=CC(O)=CC3
Storage Refer to Certificate of Analysis (CoA) for storage conditions
Shipping Room temperature in continental US; may vary elsewhere.
Catalog no. (Mfr.) HY-165368
Main SKU BHB21902387
Inhibitors

Compound Overview

Atromentin, a phthalide derivative that can be isolated from the wood fungus Hypoxylon fendleri BCC32408, is a selective inhibitor of enoyl-ACP reductase FabK, with an IC50 of 0.24 μM. It shows selectivity over FabI and can be used in antimicrobial research[1][2]. Its molecular formula is C18H12O6, with a molecular weight of 324.29 g/mol.

Physical & Chemical Properties

CAS Number 519-67-5
Molecular Formula C18H12O6
Molecular Weight 324.29 g/mol
Structure Classification Phenols Polyphenols
SMILES O=C1C(O)=C(C(=O)C(O)=C1C=2C=CC(O)=CC2)C=3C=CC(O)=CC3
Signaling Pathway Anti-infection
Initial Source Microbial — fungus F010248
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping Room temperature in continental US; may vary elsewhere.

Literature Cited

Sources cited in this description. Peer-reviewed publications that used this product are listed under References.

[1]. Zheng CJ, et al. Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae. J Antibiot (Tokyo). 2006 Dec;59(12):808-12.

[2]. Intaraudom C, et al. Antimicrobial drimane - phthalide derivatives from Hypoxylon fendleri BCC32408. Fitoterapia. 2019 Oct;138:104353.

Safety

For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.

Q.Why is there no price listed?
A.Every size of this product is quoted on inquiry. Send us the size you need and we will come back with price and lead time.
Q.Can this be used in humans or for diagnostics?
A.No. This product is supplied For Research Use Only. It is not for diagnostic or therapeutic procedures and not for human or veterinary use.

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