| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-(1-adamantyl)-N-[2-[2-(2-hydroxyethylamino)ethylamino]quinolin-5-yl]acetamide;dihydrochloride.
- Also known as: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]- 2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride
- CAS number: 607378-18-7
- Molecular formula: C25H36Cl2N4O2 (C25H34N4O2 · 2HCl).
- Purity: >97%
- Concentration: 1-100 nM.
- Form: Lyophilized Powder
- Solubility: Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 channels
- Source: Synthetic
- Activity: AZ 10606120 dihydrochloride is a potent and selective non-competitive antagonist of P2X7 receptors, acting as a negative allosteric modulator shown to inhibit human P2X7 receptors with pIC50 of 8.1-8.91-3. It also inhibits growth and neoangiogenesis of P2X7-expressing tumors in mice4.
- Alternative names: N-[2-[[2-[(2-Hydroxyethyl)amino]ethyl]amino]-5-quinolinyl]- 2-tricyclo[3.3.1.13,7]dec-1-ylacetamide dihydrochloride
Scientific background
AZ 10606120 dihydrochloride is a potent and selective noncompetitive antagonist of the P2X7 receptor with IC50 value of ~10 nM2. The compound shows little or no effect at other P2X receptor subtypes1,2. In studies conducted in animal models, AZ 10606120 treatment shows antidepressant effects and reduces tumor growth2.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. Seven members of this family have been identified and function in homomeric or heteromeric combinations. P2X7 receptor is a therapeutic target due to its potential involvement in pain and inflammatory disorders1,2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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