AZD6244

AZD6244 (also known as Selumetinib) is a selective MEK1 inhibitor that blocks the phosphorylation of ERK1/2, key components of the MAPK/ERK signaling pathway. While it has been extensively studied in oncology for its ability to suppress tumor growth, its modulation of MAPK signaling has implications for neuroscience. Dysregulation of the MAPK/ERK pathway is associated with neuroinflammation, synaptic dysfunction, and neuronal death in various neurodegenerative diseases. AZD6244’s ability to modulate this pathway positions it as a potential therapeutic candidate for conditions such as Alzheimer’s disease and multiple sclerosis. Its pharmacological profile and ability to cross the blood-brain barrier make it a compound of interest for translational neuroscience research.

Classification: Serious Eye Damage/Eye Irritation, Category 1

Skin Sensitization, Category 1

Toxic To Reproduction, Category 2

Target Organ Systemic Toxicity (repeated exposure), Category 2

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

H318:

Causes serious eye damage.

H317:

May cause an allergic skin reaction.

H361:

Suspected of damaging fertility or the unborn child.

H373:

May cause damage to {Liver, gastrointestinal tract and other major organs} through prolonged or repeated exposure.

P280:

Wear {protective gloves/protective clothing/eye protection/face protection}.

P261:

Avoid breathing {dust/fume/gas/mist/vapours/spray}.

P272:

• Contaminated work clothing should not be allowed out of the workplace.
• P362+364: Take off contaminated clothing and wash it before reuse.

P201:

Obtain special instructions before use.

P202:

Do not handle until all safety precautions have been read and understood.

P281:

Use personal protective equipment as required.

P260:

• Do not breathe {dust/fume/gas/mist/vapours/spray}.
• P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P310:

• Immediately call a {POISON CENTER/doctor/...}.
• P302+352: IF ON SKIN: Wash with plenty of soap and water.
• P333+313: If skin irritation or rash occurs, seek medical advice/attention.
• P308+313: IF exposed or concerned: Get medical attentiodvice.

P314:

Get medical attentiodvice if you feel unwell.

AZD6244 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-495)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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