| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C69H113N13O17 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Azido-PEG4-Val-Cit-PAB-MMAE is an agent-linker conjugate for ADC use, pairing the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor) with the cleavable linker Azido-PEG4-Val-Cit-PAB-OH[1]. As a click chemistry reagent it carries an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules bearing DBCO or BCN groups. It is supplied as a white to off-white solid (C69H113N13O17, MW 1396.71) at 99.43% purity.
Physical & Chemical Properties
| CAS Number | 1869126-64-6 |
|---|---|
| Molecular Formula | C69H113N13O17 |
| Molecular Weight | 1396.71 g/mol |
| Purity | 99.43% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)=O)=O)=O)=O)OC)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: H2O: < 0.1 mg/mL (insoluble) |
| Storage | -20°C, protect from light, stored under nitrogen. The compound is unstable in solutions, freshly prepared is recommended. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Moreadith R, et al. Polyoxazoline antibody drug conjugates. WO2016019340A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | < 0.1 mg/mL | insoluble |
The manufacturer notes that the compound is unstable in solution; prepare solutions fresh before use.
Data provided by the manufacturer.
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NIR-II aza-BODIPY Platform for the Development of a Fluorescent Antibody Drug Conjugate. J Med Chem 2025 Mar 28. PMID: 40152348
