| Field | Specification |
|---|---|
| Alternative names | 2-Azidoacetic acid |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C2H3N3O2 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Azidoacetic Acid (compound 92-1), also known as 2-Azidoacetic acid, is a click chemistry reagent bearing an azide group and can serve as a small-molecule tool for PROTAC synthesis[1]. The azide group allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules, as well as ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules bearing DBCO or BCN groups. It is supplied as a colorless to light yellow liquid (C2H3N3O2, MW 101.06) at 99.09% purity.
Physical & Chemical Properties
| CAS Number | 18523-48-3 |
|---|---|
| Molecular Formula | C2H3N3O2 |
| Molecular Weight | 101.06 g/mol |
| Purity | 99.09% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| Density | 1.350 g/cm3 |
| SMILES | [N-]=[N+]=NCC(O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Solubility | In Vitro: H2O: 100 mg/mL (989.51 mM; Requires sonication) |
| Storage | Pure form: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Ma Xin et al. Class of novel Smad3 protein degraders and application. Patent WO2022148459A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 100 mg/mL (989.51 mM) | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
Data provided by the manufacturer.
In Vitro
Click chemistry refers to selective, modular, wide-ranging, high-yield chemical reactions that enable rapid synthesis of new compounds by linking heteroatoms (C-X-C). Bertozzi extended click chemistry into a new dimension, bioorthogonal chemistry, which is defined as a rapid and selective reaction that leaves biological processes undisturbed under physiological conditions. Common reaction structures used in click chemistry include Azide, Alkyne, DBCO, BCN, TCO and Tetrazine.
Data provided by the manufacturer.
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