| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)-4-piperidinone |
| Cas No. | |
| Form | Pale Yellow Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 35 mg/ml DMSO |
| Source | Synthetic |
| Storage |
b-AP15 is a selective inhibitor of the deubiquitinating enzymes UCHL5 and USP14, which are associated with the 19S regulatory particle of the proteasome. By blocking these enzymes, b-AP15 disrupts the removal of ubiquitin chains from proteasome substrates, leading to accumulation of polyubiquitinated proteins and induction of apoptosis. This mechanism has been explored in cancer models, but also holds relevance in neurodegenerative disease research, where impaired proteasomal degradation and protein aggregation are hallmark features. b-AP15 provides a valuable tool for studying the role of deubiquitination in neuronal proteostasis and may inform therapeutic strategies targeting the ubiquitin-proteasome system in disorders such as ALS and Huntington’s disease.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
b-AP15 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-339)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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