| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H23Br2Cl2N3O |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
BAI1 hydrochloride is a selective allosteric inhibitor of the apoptosis factor BAX, binding BAX and allosterically blocking its activation. It has been studied for potential use in research on BAX-dependent cell death-mediated diseases[1]. It is supplied as a white to off-white solid (C19H23Br2Cl2N3O, MW 540.12) at 99.82% purity.
Physical & Chemical Properties
| CAS Number | 329349-20-4 |
|---|---|
| Molecular Formula | C19H23Br2Cl2N3O |
| Molecular Weight | 540.12 g/mol |
| Purity | 99.82% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | BrC1=CC=C2C(C3=C(N2CC(CN4CCNCC4)O)C=CC(Br)=C3)=C1.Cl.Cl |
| Signaling Pathway | Apoptosis |
| Solubility | In Vitro: DMSO: 5 mg/mL (9.26 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O: < 0.1 mg/mL (insoluble) |
| Storage | -20°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 5 mg/mL (9.26 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
| H2O | < 0.1 mg/mL | insoluble |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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Adv Funct Mater. 2023 Apr 28.
A multifaceted strategy for intra- and extracellular nucleic acid regulation to alleviate intervertebral disc degeneration. Nat Commun 2025 Aug 26;16(1):7936. PMID: 40858573
DLK-dependent axonal mitochondrial fission drives degeneration after axotomy. Nat Commun 2024 Dec 30;15(1):10806. PMID: 39737939
Apoptotic dysregulation mediates stem cell competition and tissue regeneration. Nat Commun 2023 Nov 20;14(1):7547. PMID: 37985759
Cyclic mechanical stretch suppresses intrinsic apoptosis in high metastatic melanoma. Mater Today Bio 2026 Apr 22:38:103132. PMID: 42111771
Targeting STING alleviates pyroptosis of bladder epithelial cells and ameliorates bladder fibrosis in neurogenic bladder. Biochem Pharmacol 2025 Jul 17:117177. PMID: 40683470
Dietary advanced glycation end-products exacerbate sarcopenia onset by activating apoptosis through PRMT1-mediated CRTC3 arginine methylation. Cell Mol Life Sci 2025 Apr 7;82(1):142. PMID: 40192801
BAX pores facilitate mitochondrial DNA release in wasp sting-induced acute kidney injury. Int Immunopharmacol 2024 Oct 21;143(Pt 2):113424. PMID: 39437488
Mitochondrial Trafficking of MLKL, Bak/Bax, and Drp1 Is Mediated by RIP1 and ROS which Leads to Decreased Mitochondrial Membrane Integrity during the Hyperglycemic Shift to Necroptosis. Int J Mol Sci 2023 May 11;24(10):8609. PMID: 37239951
Pannexin1 promotes cellular senescence by triggering mtDNA release to activate the cGAS-STING pathway. Biochim Biophys Acta Mol Basis Dis 2026 Jul 28;1873(1):168388. PMID: 42521040
