| Field | Specification |
|---|---|
| Alternative names | Bay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C10H9NO2S |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble to 25 mM in ethanol and to 100 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | White solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
BAY 11-7082 is an anti-inflammatory compound that inhibits cytokine-induced phosphorylation of IκBα, thereby suppressing NF-κB activation. It also functions as an inhibitor of E2 ubiquitin-conjugating enzymes and can induce apoptosis. In neurodegenerative disease research, BAY 11-7082 is used to study the role of NF-κB signaling in neuroinflammation, glial activation, and neuronal survival. Its ability to modulate inflammatory pathways makes it a valuable tool for investigating therapeutic strategies aimed at reducing chronic inflammation in diseases such as Alzheimer’s, ALS, and multiple sclerosis.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
BAY 11-7082 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-434)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.
