| Field | Specification |
|---|---|
| Target | |
| Applications | |
| Molecular weight | |
| Molecular formula | C28H32FNO2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
BChE-IN-16 is a highly potent inhibitor of BChE, with an IC50 of 3.8 nM against hBChE. It exhibits low cytotoxicity, potential CNS permeability and notable structural adaptability, and it can be used in Alzheimer's disease research. It has the molecular formula C28H32FNO2 and a molecular weight of 433.56 g/mol.
Physical & Chemical Properties
| Molecular Formula | C28H32FNO2 |
|---|---|
| Molecular Weight | 433.56 g/mol |
| SMILES | COC1=CC=CC(CN(C2CCC2)CCCC3=C(C=CC=C3)F)=C1OCC4=CC=CC=C4 |
| Target | hBCHE |
| Signaling Pathway | Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
hBCHE 3.8 nM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
BChE-IN-16 does not inhibit hAChE, with an IC50 value above 10 μM[1]. hBChE is competitively inhibited by BChE-IN-16, with a Ki value of 4.04 nM[1]. Cytotoxicity of BChE-IN-16 toward SH-SY5Y cells is shown by an IC50 value of 87.0 μM[1]. In HepG2 cells, BChE-IN-16 is cytotoxic with an IC50 value of 76.0 μM[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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