| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H22Cl2N2O2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
BCPA is a Pin1 regulator that lacks cytotoxicity. It attenuates the reduction of Pin1 protein, inhibiting receptor activator of RANKL-induced osteoclastogenesis, and it regulates osteoclast activation, which supports its use in osteoporosis research[1]. It is supplied as a white to light yellow solid (C22H22Cl2N2O2, MW 417.33) at 98.27% purity.
Physical & Chemical Properties
| CAS Number | 547731-67-9 |
|---|---|
| Molecular Formula | C22H22Cl2N2O2 |
| Molecular Weight | 417.33 g/mol |
| Purity | 98.27% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | O=C(NCCCCNC(/C=C/C1=C(Cl)C=CC=C1)=O)/C=C/C2=C(Cl)C=CC=C2 |
| Signaling Pathway | PI3K/Akt/mTOR |
| Solubility | In Vitro: DMSO: 6.67 mg/mL (15.98 mM; Requires sonication and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Cho E, et al. BCPA {N, N′-1, 4-Butanediylbis [3-(2-chlorophenyl) acrylamide]} Inhibits osteoclast differentiation through increased retention of peptidyl-prolyl cis-trans isomerase never in mitosis A-interacting 1[J]. International Journal of Molecular Sciences, 2018, 19(11): 3436.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 6.67 mg/mL (15.98 mM) | requires sonication and warming and heat to 80°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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