| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | VX-970 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Berzosertib (CAS 1232416-25-9) is a research-grade small molecule supplied by TargetMol.
Alternative names: VX-970
Physical Properties
| CAS Number | 1232416-25-9 |
|---|---|
| Molecular Formula | C24H25N5O3S |
| Molecular Weight | 463.55 g/mol |
| SMILES | NC=1C(=NC(=CN1)C2=CC=C(S(C(C)C)(=O)=O)C=C2)C3=CC(=NO3)C4=CC=C(CNC)C=C4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Berzosertib (VE-822) has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid Neoplasm, among others.
Target(s): ATM/ATR
Signaling pathway(s): PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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