| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H19ClN6O |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
β-catenin-IN-6 inhibits β-catenin, targeting the canonical Wingless-related integration site signaling pathway. It suppresses proliferation of human colorectal cancer cells and shows this effect in a β-catenin/RK3E mouse model as well[1][2]. It is supplied as a white to off-white solid (C22H19ClN6O, MW 418.88) at 98.65% purity.
Physical & Chemical Properties
| CAS Number | 1039731-99-1 |
|---|---|
| Molecular Formula | C22H19ClN6O |
| Molecular Weight | 418.88 g/mol |
| Purity | 98.65% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(C1=CN=C(C=C1)Cl)NC2=CC=C(CNC3=C4C=CC=CC4=NC(NC)=N3)C=C2 |
| Signaling Pathway | Stem Cell/Wnt |
| Solubility | In Vitro: DMSO: 100 mg/mL (238.73 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (238.73 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
β-catenin-IN-6 (24 h) shows inhibition in LoVo and HT29 cells, with IC50s of 1.4 μM and 1.37 μM, respectively. Cell growth inhibition by β-catenin-IN-6 is also seen across several human colorectal cancer lines[1].
In Vivo
Poor bioavailability is reported for β-catenin-IN-6[1]. In a mouse model, β-catenin-IN-6 (18.75 mg/kg; ip; once daily for 7 days) lowers tumor volume without affecting body weight[1]. In a β-catenin/RK3E mouse model, β-catenin-IN-6 (150 mg/kg; ip; once per week) suppresses growth of xenograft tumors[2].
| Animal Model | Nude mice bearing subcutaneous β-catenin/ RK3E tumors[1][2] |
|---|---|
| Dosage | 18.75 mg/kg, 37.5 mg/kg, 75.1 mg/kg, 150 mg/kg |
| Administration | IP; once daily for 7 days |
| Result | Inhibited tumor growth up to 66% in mouse model. Showed dose-dependently inhibition on tumor growth and volume. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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