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Compound Overview
β-Glucuronide-dPBD-PEG5-NH2 (CAS 2246363-68-6) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2246363-68-6 |
|---|---|
| Molecular Formula | C78H101N7O35 |
| Molecular Weight | 1696.66 g/mol |
| SMILES | (H)(C)12CC(=C)CN1C(=O)c1cc(OC)c(OCCCCCOc3cc4N(C(O)(C)5((H))CC(=C)CN5C(… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
beta-Glucuronide-dPBD-PEG5-NH2 is a beta-glucuronide-linked pyrrolobenzodiazepine dimer that functions as a proagent for the synthesis of the antibody-drug conjugate (ADC) cIRCR201-dPBD, utilizing a cleavable beta-glucuronide linkage. This compound targets and binds to the prenylated antibody, facilitating the controlled release of the drug and thereby mitigating side effects. Furthermore, beta-Glucuronide-dPBD-PEG5-NH2 exhibits antitumor properties by inducing apoptosis and arresting the cell cycle (1).
Target(s): Others, Drug-Linker Conjugates for ADC
Signaling pathway(s): Antibody-drug Conjugate/ADC Related, Others
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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