Bexarotene

Bexarotene is a highly potent and selective retinoid X receptor (RXR) agonist, originally developed as an antineoplastic agent for cutaneous T-cell lymphoma. In neuroscience, Bexarotene has garnered significant attention for its ability to enhance the clearance of soluble β-amyloid and improve cognitive function in animal models of Alzheimer’s disease. It has also been shown to reverse apoE4-driven brain pathology and behavioral deficits, highlighting its potential in targeting genetic risk factors for neurodegeneration. By modulating lipid metabolism, inflammation, and gene expression, Bexarotene represents a promising therapeutic avenue for neurodegenerative diseases. Its dual role in oncology and neurology underscores its versatility and scientific impact.

Classification: Not a hazardous substance or mixture.

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Bexarotene (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-535)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

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Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).