| Field | Specification |
|---|---|
| Target | |
| Alternative names | LP352 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C15H19F2N3O |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Bexicaserin (LP352) is a 5-HT2C receptor agonist with potential for studying obesity and psychiatric-related disorders such as epilepsy[1][2]. It is supplied as a white to off-white solid (C15H19F2N3O, MW 295.33).
Physical & Chemical Properties
| CAS Number | 2035818-24-5 |
|---|---|
| Molecular Formula | C15H19F2N3O |
| Molecular Weight | 295.33 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | FC(F)CNC(C1=C2C3=C(C=C1)CNCCN3C[C@@H]2C)=O |
| Target | 5-HT 2C Receptor |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Solubility | In Vitro: DMSO: 50 mg/mL (169.30 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[2]. Kaye R, et al. Searching for safer and more effective medications in the management of seizure disorders: a 5-HT2C superagonist[C]//EPILEPSIA. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY, 2023, 64: 315-315.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 50 mg/mL (169.30 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (8.47 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Protocol 2
| Composition | 10% DMSO + 90% (20% SBE-β-CD in saline) |
|---|---|
| Result | ≥ 2.5 mg/mL (8.47 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL 20% SBE-β-CD in saline. 20% SBE-β-CD in saline: dissolve 2 g SBE-β-CD powder in 10 mL saline until clear (4°C, store up to one week). |
Protocol 3
| Composition | 10% DMSO + 90% Corn Oil |
|---|---|
| Result | ≥ 2.5 mg/mL (8.47 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). Use with caution if continuous dosing will exceed two weeks. For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 900 μL corn oil. |
Data provided by the manufacturer.
In Vitro
At 10 μM for 24 or 48 hours, Bexicaserin acts as a superagonist of the 5-HT2C receptor (a ligand eliciting a larger response than the endogenous agonist) and its Ki is 44 nM. In dynamic mass redistribution (DMR) assays, Bexicaserin elicited a maximal cellular response in HEK293 cells expressing the human 5-HT2C receptor, higher than the response elicited by the endogenous agonist 5-HT[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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