| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C32H37N3O4S |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
BI 703704 is a potent activator of soluble guanylate cyclase (sGC) that inhibits the progression of diabetic nephropathy in the ZSF1 rat[1]. It is supplied as a white to off-white solid with the molecular formula C32H37N3O4S and a molecular weight of 559.72 g/mol.
Physical & Chemical Properties
| CAS Number | 2740807-77-4 |
|---|---|
| Molecular Formula | C32H37N3O4S |
| Molecular Weight | 559.72 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC1=CC(C2=CSC(N3C[C@H](CC4)[C@@H](C(O)=O)[C@H]4C3)=N2)=C(OCC5=CC=C(C(N6CCCCC6)=O)C=C5C)C=C1 |
| Signaling Pathway | GPCR/G Protein |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vivo
Given daily for 15 weeks (0.3-10 mg/kg; food intake), BI 703704 lowers urinary protein excretion (UPE) and raises renal cGMP content, both in a dose-dependent manner[1]. BI 703704 effectively elevates renal cGMP levels dose-dependently and slows the progression of diabetic nephropathy in an oxidative stress milieu[1].
| Animal Model | Fifty-eight male ZSF1 rats (12-13 weeks)[1] |
|---|---|
| Dosage | 0.3, 1, 3, or 10 mg/kg |
| Administration | Food intake; daily for 15 weeks |
| Result | Resulted in dose-dependent decreases in urinary protein excretion (UPE), and a dose-dependent increase in renal cGMP content. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).
