| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C33H37F6N7O7 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
BIBO3304 diTFA is an orally effective, selective antagonist of the neuropeptide Y (NPY) Y1 receptor, with high affinity for both human and rat Y1 receptors, showing IC50 values of 0.38 nM and 0.72 nM, respectively. It promotes bone-tendon healing through the Wnt/β-catenin signaling pathway[1][2][3]. It has the molecular formula C33H37F6N7O7 and a molecular weight of 757.68 g/mol.
Physical & Chemical Properties
| CAS Number | 2310085-85-7 |
|---|---|
| Molecular Formula | C33H37F6N7O7 |
| Molecular Weight | 757.68 g/mol |
| SMILES | O=C(N[C@@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F |
| Signaling Pathway | Stem Cell/Wnt; GPCR/G Protein; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord. Nat Commun 2025 Aug 1;16(1):7074. PMID: 40750771
Feedforward inhibition of stress by brainstem neuropeptide Y neurons. Nat Commun 2024 Sep 1;15(1):7603. PMID: 39217143
Distinct contribution of spinal neuropeptide Y and NPY1R neurons to morphine analgesia. Brain 2026 Feb 25:awag077. PMID: 41738433
Ghrelin Induces the Production of Hypothalamic NPY Through the AMPK-mTOR Pathway to Alleviate Cancer-induced Bone Pain. In Vivo 2024 May-Jun;38(3):1133-1142. PMID: 38688635
