| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Afatinib, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide |
| Cas No. | |
| Form | Crystalline solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml |
| Source | Synthetic |
| Storage |
BIBW 2992 (Afatinib) is a potent and irreversible inhibitor of the ErbB family of receptors, including EGFR and HER2. Primarily developed for oncology applications, particularly in non-small cell lung cancer, its inhibition of EGFR signaling has broader implications. In the nervous system, EGFR signaling is involved in neurodevelopment, synaptic plasticity, and response to injury. Although BIBW 2992 is not widely used in neuroscience, its mechanism of action suggests potential utility in modulating neuroinflammatory responses and glial activation. Further research may uncover its relevance in neurodegenerative disease models where aberrant EGFR signaling contributes to pathology.
Acute Toxicity:
Oral, Category 2
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 1
Toxic To Reproduction, Category 2
Target Organ Systemic Toxicity (repeated exposure), Category 2
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
H300:
Fatal if swallowed.
H315:
Causes skin irritation.
H318:
Causes serious eye damage.
H361:
Suspected of damaging fertility or the unborn child.
H373:
May cause damage through prolonged or repeated exposure.
P264:
Wash {hands} thoroughly after handling.
P280:
- Wear {protective gloves/protective clothing/eye protection/face protection}.
- P362+364: Take off contaminated clothing and wash it before reuse.
P201:
Obtain special instructions before use.
P202:
Do not handle until all safety precautions have been read and understood.
P281:
Use personal protective equipment as required.
P260:
- Do not breathe {dust/fume/gas/mist/vapours/spray}.
- P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330:
- Rinse mouth.
- P302+352: IF ON SKIN: Wash with plenty of soap and water.
- P332+313: If skin irritation occurs, get medical advice/attention.
- P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310:
- Immediately call a {POISON CENTER/doctor/...}.
- P308+313: IF exposed or concerned: Get medical attentiodvice.
P314:
Get medical attentiodvice if you feel unwell.
BIBW 2992 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-496)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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