| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: (5aR- (3aS*,5aα,8b,8aS*,9a,10aα))- 9-(1,1-dimethylethyl)- 10,10a-dihydro- 8,9-dihydroxy- 4H,5aH,9H-furo[2,3-b]furo[3',2':2,3]cyclopenta[1,2-c]furan- 2,4,7(3H,8H)-trione.
- CAS number: 33570-04-6
- Molecular formula: C15H18O8.
- Purity: >99.5%
- Concentration: 1-100 µM.
- Form: Lyophilized Powder
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-HT3A, GABA(A) receptors
- Source: Natural
- Activity: Bilobalide is a 5-HT3A1 and GABAA2 channel blocker.
Scientific background
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the Cys-loop channel family1.The GABA(A) receptor is also a ligand-gated ion channel. It is the major receptor type for the GABA inhibitory neurotransmitter in the central nervous system2.Bilobalide is a natural non-selective blocker of the 5-HT3A and GABA(A) channels. Bilobalide is a sesquiterpene trilactone extracted from the leaves of the tree Ginkgo biloba. Bilobalide has an effective concentration of 1-100 μM and an IC50 of 470 μM for the 5-HT3A receptor3 and an IC50 of 4.6±0.5 μM for the GABA(A) receptor. Bilobalide also binds to other anion Cys-loop receptors such as glycine receptors with a much higher affinity than to the 5-HT3A receptor.Bilobalide inhibits direct GABA mediated currents from recombinant human GABA(A) receptors thus suggesting it enhances neuronal excitability. Bilobalide is used in traditional Japanese medicine as a memory enhancer, treating symptoms associated with mild-moderate dementia and improving cognitive functions related to old age and senility3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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