| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride |
| Cas No. | |
| Form | Cream solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (100 mM) or Water (100 mM) |
| Source | Synthetic |
| Storage |
BIX-01294 is a selective inhibitor of G9a and G9a-like protein histone lysine methyltransferases, with IC50 values of 0.7 and 1.7 µM, respectively. It modulates H3K9me2 levels in mammalian cells and has been instrumental in studies of epigenetic regulation and cellular reprogramming. In neuroscience, BIX-01294’s ability to alter chromatin states and gene expression profiles makes it a valuable tool for investigating neurodevelopmental processes and neuroplasticity. Its role in facilitating the induction of pluripotent stem cells also opens avenues for regenerative medicine and modeling of neurological diseases. Although primarily used in stem cell and cancer research, its epigenetic effects are increasingly relevant to understanding and potentially treating neurodegenerative disorders.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
BIX-01294 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-347)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574.
3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.
