| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Chk2 Inhibitor II, Chk2 Inhibitor II hydrate, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide hydrate |
| Cas No. | |
| Form | Off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml) |
| Source | Synthetic |
| Storage |
Bml 277 is a highly selective inhibitor of checkpoint kinase 2 (Chk2), a key component of the DNA damage response pathway. In neuroscience, Chk2 is studied for its role in neuronal apoptosis and genomic stability under stress conditions. Bml 277 is used to investigate the contribution of Chk2 signaling to neurodegenerative processes, particularly in models of oxidative stress, ischemia, and neuroinflammation. Its selectivity makes it a valuable tool for dissecting DNA repair mechanisms and their impact on neuronal survival.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Bml 277 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-436)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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