| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C60H96N20O21S2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Boanmycin is an antibiotic with antitumor activity that induces cellular senescence and apoptosis[1][2][3]. It has the molecular formula C60H96N20O21S2 (MW 1497.66).
Physical & Chemical Properties
| CAS Number | 37293-17-7 |
|---|---|
| Molecular Formula | C60H96N20O21S2 |
| Molecular Weight | 1497.66 g/mol |
| SMILES | O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(NCCCNCCCCNCCCN)=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O |
| Signaling Pathway | Anti-infection; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
Boanmycin can induce apoptosis and can block cell cycle progression at the G2/M phase in Eca-109 cells at 50-125 μg/mL over 0.5-36 h[2]. At 6.7 μg/mL for 24 h, Boanmycin induces cell senescence[3].
Cell Viability Assay[3]
| Cell Line | Human lung fibroblast cell line IMR90, mouse primary osteoblasts (OBs) |
|---|---|
| Concentration | 6.7 μg/mL |
| Incubation Time | 24 hours |
| Result | Showed a 90% positive number of SA-βgal stained cells in IMR90 cells and 95% in OBs compared to 30% in the control group. |
RT-PCR[3]
| Cell Line | Mouse primary osteoblasts (OBs) |
|---|---|
| Concentration | 6.7 μg/mL |
| Incubation Time | 24 hours |
| Result | Increased senescence-associated secretory phenotype (SASP) factor IL-6 expression up to six-fold. |
In Vivo
In BALB/c nude mice carrying HT-29, Hce-8693, or CT-26 cells, Boanmycin (BAM) can effectively inhibit tumor growth when given i.p. at 10 or 15 mg/kg twice a week for 5 weeks[1].
| Animal Model | BALB/c nude mice with HT-29 or Hce-8693 cells[1] |
|---|---|
| Dosage | 10 or 15 mg/kg |
| Administration | Intraperitoneal injection; twice a week; 5 weeks |
| Result | Significantly inhibited tumor growth by 89% at 10 mg/kg and by 92% at 15 mg/kg in mice with HT-29 model, also inhibited tumor growth by 90% at 10 mg/kg and by 92% at 15 mg/kg in mice with Hce-8693 model. |
| Animal Model | BALB/c nude mice with CT-26 cells[1] |
|---|---|
| Dosage | 10 mg/kg |
| Administration | Intramuscular injection; every second day; 10 times |
| Result | Inhibited subcutaneous tumor growth by 88% and cecal tumor by 99%. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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