| Field | Specification |
|---|---|
| Alternative names | B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; Radiciol; NSC 681239; DPBA; LDP 341; MG 341; mlN 341; NSC 681239; PS 314; PS 341; Radiciol; Velcade |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C19H25BN4O4 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble in 50 mg/ml DMSO, 35 mg/ml Ethanol |
| SMILES | |
| InChIKey | |
| Form | White Powder |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Bortezomib is a potent and selective reversible inhibitor of the 20S proteasome. It blocks NFκB activation, inhibits tumor cell proliferation, and suppresses angiogenesis. In neuroscience, Bortezomib is used to study proteasome-mediated protein turnover and its role in neuroinflammation, synaptic remodeling, and neurodegenerative pathways such as those implicated in Alzheimer's and Parkinson's disease.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Bortezomib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-328)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
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2. Williams S., et al. (2003) Mol. Cancer Ther. 2: 835.
