| Field | Specification |
|---|---|
| Alternative names | Bisperoxovanadium |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C6H4K2NO8V |
| Purity | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
BpV(HOpic), also known as Bisperoxovanadium, is a potent, selective inhibitor of PTEN with an IC50 of 14 nM. A nanocarrier formulation of BpV(HOpic) has been reported to show neuroprotective activity[1][2]. It is supplied as a light yellow to yellow solid (C6H4K2NO8V, MW 347.24) at 95.0% purity.
Physical & Chemical Properties
| CAS Number | 722494-26-0 |
|---|---|
| Molecular Formula | C6H4K2NO8V |
| Molecular Weight | 347.24 g/mol |
| Purity | 95.0% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| Signaling Pathway | PI3K/Akt/mTOR |
| Solubility | In Vitro: H2O: 50 mg/mL (143.99 mM; Requires sonication and warming and heat to 60°C) DMSO: 2.89 mg/mL (8.32 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | -20°C, sealed storage, away from moisture. The compound is unstable in solutions, freshly prepared is recommended. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 14 nM (PTEN)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 50 mg/mL (143.99 mM) | requires sonication and warming and heat to 60°C |
| DMSO | 2.89 mg/mL (8.32 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
The manufacturer notes that the compound is unstable in solution; prepare solutions fresh before use.
Data provided by the manufacturer.
In Vitro
In MG63 cells treated with Cisplatin, BpV(HOpic) (1 μM) increases cell proliferation and lowers the apoptotic rate[3]. Bpv(HOpic) (1 μM) promotes migration of C2C12 myoblasts, associated with activation of the PI3K/AKT and MAPK/ERK signalling pathways[4]. BpV(HOpic) (1 μM; 48 hours) promotes initiation of swine follicle growth and development, as is seen in rodent species and humans[5]. Nanocarrier-BpV(HOpic) improves axonal outgrowth in neurons[2].
In Vivo
In vivo, BpV(HOpic) (0.05 mg/kg; i.p.) given at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury[6]. In mice with ischemia/reperfusion injury (IRI), BpV(HOpic) (200 μg/kg; i.p.) worsens renal dysfunction and promotes tubular damage[7].
| Animal Model | Male Wistar rats are subjected to partial hepatic ischemia[6] |
|---|---|
| Dosage | 0.05 mg/kg |
| Administration | I.p. injections at the start of reperfusion |
| Result | Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation. |
| Animal Model | Male C57BL/6 mice (8-12 weeks old; 20-30 g) are subjected to renal ischemia[7] |
|---|---|
| Dosage | 200 μg/kg |
| Administration | I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr |
| Result | Raised the level of serum creatinine and blood serum urea nitrogen. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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FBP1 controls liver cancer evolution from senescent MASH hepatocytes. Nature 2025 Jan;637(8045):461-469. PMID: 39743585
Establishment of a trastuzumab-resistant extramammary Paget disease model: loss of PTEN as a potential mechanism. Br J Cancer 2024 Sep;131(5):944-953. PMID: 38987365
Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo. Cancer Cell Int 2021 Dec 19;21(1):689. PMID: 34923996
METTL3-mediated N6-methyladenosine modification contributes to vascular calcification. J Mol Cell Cardiol 2025 Apr 11:S0022-2828(25)00064-1. PMID: 40222552
Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways. J Mater Sci Mater Med 2024 Jul 29;35(1):42. PMID: 39073469
Reduced PTCH2 expression is associated with glioma development through its regulation of the PTEN/AKT signaling pathway. Biochem Biophys Res Commun 2022 Oct 30:627:76-83. PMID: 36027694
PFKP Lactylation Promotes the Ovarian Cancer Progression Through Targeting PTEN. Biochem Genet 2024 Dec 5. PMID: 39638933
