| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C12H8KN2O5V |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
bpV(phen), an insulin-mimetic agent, is a potent inhibitor of protein tyrosine phosphatases (PTP) and PTEN, with IC50 values of 38 nM, 343 nM and 920 nM against PTEN, PTP-β and PTP-1B, respectively. It suppresses proliferation of the protozoan parasite Leishmania in vitro, drives strong secretion of numerous chemokines and pro-inflammatory cytokines, and activates a Th1-type pathway (IL-12, IFNγ). It can also induce cell apoptosis and shows anti-angiogenic and anti-tumor activity[1][2][3][4][5]. It is supplied as a light yellow to yellow solid (C12H8KN2O5V, MW 350.24) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 42494-73-5 |
|---|---|
| Molecular Formula | C12H8KN2O5V |
| Molecular Weight | 350.24 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=[V+3]12([N]3=CC=C4)([O-][O-]1)([O-][O-]2)[N]5=C6C3=C4C=CC6=CC=C5.[K+] |
| Signaling Pathway | PI3K/Akt/mTOR; Metabolic Enzyme/Protease; Anti-infection; Apoptosis |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 38 nM (PTEN), 343 nM (PTP-β) and 920 nM (PTP-1B)[3] Parasite Leishmania[2] Apoptosis[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
In H/R-injured H9c2 cells, bpV(phen) (5 μM; 24.5 hours) further decreases cell viability[1]. bpV(phen) (5 μM; 24.5 hours) raises apoptosis in H/R-injured H9c2 cells[1]. Cytoplasmic Cytochrome C accumulates significantly more in H/R-injured H9c2 cells treated with bpV(phen) (5 μM; 24.5 hours)[1]. PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited following bpV(phen) stimulation[1]. bpV(phen) acts as an insulin mimetic after insulin-receptor tyrosine kinase hyperphosphorylation and activation[4].
Cell Viability Assay[1]
| Cell Line | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
|---|---|
| Concentration | 5 μM |
| Incubation Time | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
| Result | Caused a further decrease of cell viability. |
Apoptosis Analysis[1]
| Cell Line | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
|---|---|
| Concentration | 5 μM |
| Incubation Time | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
| Result | Increased the apoptosis of H/R-injured H9c2 cells. |
Western Blot Analysis[1]
| Cell Line | Hypoxia/reoxygenation (H/R)-injured H9c2 cells |
|---|---|
| Concentration | 5 μM |
| Incubation Time | 24.5 hours (hypoxia for 24 h; reoxygenation for 30 minutes) |
| Result | Showed an increased release of Cytochrome C. |
In Vivo
In male BALB/c nude (nu/nu) athymic mice, bpV(phen) (5 mg/kg; intraperitoneal injection; daily; for 38 days) significantly reduces average tumor volume[1].
| Animal Model | Male BALB/c nude (nu/nu) athymic mice (6-7 weeks old) injected with PC-3 cells[2] |
|---|---|
| Dosage | 5 mg/kg |
| Administration | Intraperitoneal injection; daily; for 38 days |
| Result | Caused a significant reduction in average tumor volume. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. Nat Commun 2022 May 19;13(1):2762. PMID: 35589797
MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy. Biochem Biophys Res Commun 2020 Sep 3;529(4):1045-1052. PMID: 32819563
The Guangsi Yulin Decoction Inhibits Oxidative Stress and Inflammation-Induced Spermatogenesis Dysfunction via the PTEN/ PI3K/ AKT/ FoxO1 Pathway. Am J Mens Health 2026 Mar-Apr;20(2):15579883261427164. PMID: 41807111
