| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | BRD7389, BRD-7389, 1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione, 1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione |
| Cas No. | |
| Form | Orange powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 100 mM in DMSO |
| Source | Synthetic |
| Storage |
BRD 7389 is a selective inhibitor of p90 ribosomal S6 kinases (RSK1, RSK2, and RSK3), key effectors in the MAPK/ERK signaling pathway. Although initially studied for its role in regulating insulin expression in pancreatic alpha-cells, BRD 7389’s modulation of RSK activity has implications for neuroscience. RSK signaling influences neuronal survival, synaptic plasticity, and memory formation. Dysregulation of this pathway has been implicated in neurodegenerative diseases and cognitive disorders. By targeting RSKs, BRD 7389 may serve as a tool for dissecting the molecular mechanisms underlying neuronal function and resilience, offering potential leads for therapeutic development in neurodegeneration.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
BRD 7389 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-497)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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