| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N,N,2-Trimethyl-5-nitro-benzenesulfonamide |
| Cas No. | |
| Form | Cream solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (40 mg/ml) or Ethanol (5 mg/ml) |
| Source | Synthetic |
| Storage |
BRL-50481 is a selective phosphodiesterase 7 (PDE7) inhibitor that has shown promise in modulating cyclic AMP signaling pathways. PDE7 is expressed in immune and neuronal cells, and its inhibition may reduce neuroinflammation and promote neuroprotection. While initially studied for its role in osteoporosis, BRL-50481 is gaining interest in neurodegenerative disease research for its ability to regulate intracellular signaling cascades involved in neuronal survival and plasticity. Its specificity makes it a valuable tool for dissecting PDE7-mediated mechanisms in brain health.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
BRL-50481 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-374)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Pekkinen M., et al. (2008) Bone. 43(1): 84-91.
