| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H16N2O6 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high-potency agonist of GPR35, promoting interactions between β-arrestin-2 and either human GPR35a or rat GPR35. It also functions as an antiallergic mast cell stabilizer that inhibits an anti-inflammatory response inducible by the internalization peptide, acting as an anti-inflammatory agent for research on pharmacological delivery linked with the internalization peptide[1][2][3]. It is supplied as a white to off-white solid (C18H16N2O6, MW 356.33) at 95.16% purity.
Physical & Chemical Properties
| CAS Number | 54867-56-0 |
|---|---|
| Molecular Formula | C18H16N2O6 |
| Molecular Weight | 356.33 g/mol |
| Purity | 95.16% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C1C2=C3C(C(C=C(C(O)=O)N3)=O)=CC(CCCC)=C2NC(C(O)=O)=C1 |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling; Immunology/Inflammation |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[2]. Church M K, et al. Comparison of sodium cromoglycate derivatives, anti-histamines and β-stimulants on histamine release from human lung in vitro[J]. International Archives of Allergy and Immunology, 1981, 66(Suppl. 1): 281-282.
[3]. Tymianski M, et al. Co-administration of an agent linked to an internalization peptide with an anti-inflammatory: United States, US8933013 B2. 2015-01-13.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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