| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Soluble up to 100 mM in water. Centrifuge all products before handling (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy(phosphonooxy)phosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-yl] 4-benzoylbenzoate;N,N-diethylethanamine.
- Also known as: BzATP, Benzoylbenzoyl-ATP, 2'(3')-O-(4-Benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt
- CAS number: 112898-15-4
- Molecular formula: C24H24N5O15P3 · C18H45N3.
- Purity: >95%
- Concentration: 0.5-300 µM.
- Form: Lyophilized Powder
- Solubility: Soluble up to 100 mM in water. Centrifuge all products before handling (10000 x g 5 min).
- Reconstitution: Soluble up to 100 mM in water. Centrifuge all products before handling (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X7 receptors
- Source: Synthetic
- Activity: BzATP triethylammonium salt is an agonist of the purinergic P2X7 receptor, more potent than ATP, with EC50 varying from 0.7 to 285 µM, depending on receptor species, buffer composition, serum constituents and repeated exposure to ATP. Shows partial agonist activity on other P2X receptors. Can be used as a photoaffinity label for ATPase1-3.
- Alternative names: BzATP, Benzoylbenzoyl-ATP, 2'(3')-O-(4-Benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt
Scientific background
BzATP triethylammonium salt is an agonist of the purinergic P2X7 receptor that is ten times more potent than ATP1. On rat P2X7 receptor, BzATP triethylammonium salt demonstrates an EC50 value of 6.8 µM2. The compound also shows partial agonist activity on other P2X receptors1.P2X receptors are a family of ion channels gated by ATP, a ligand that mediates numerous physiological functions. P2X receptors are widely localized in cell types of almost every origin, including neuronal, muscular, epithelial and immune, and have been shown to play a pivotal role in models of various pain conditions2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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