| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]- 4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid |
| Cas No. | |
| Form | Orange Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 10 mg/ml DMSO |
| Source | Synthetic |
| Storage |
C-646 is a potent and selective inhibitor of the histone acetyltransferase p300/CBP, with a Ki of 400 nM. In neuroscience, C-646 has been shown to enhance synaptic plasticity and memory formation, particularly in fear extinction paradigms. It also promotes tau deacetylation, thereby reducing levels of pathogenic phosphorylated tau (p-tau), a hallmark of Alzheimer’s disease. These properties position C-646 as a promising epigenetic modulator for neurodegenerative disease research, offering insights into chromatin remodeling and transcriptional regulation in neuronal health and disease.
Classification: Caution – Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
C-646 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-350)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Santer F.R., et al. (2011) Mol. Cancer Ther. 10: 1644.
3. Marek R., et al. (2011) J. Neurosci. 31: 7486.
4. Min S.W., et al. (2010) Neuron 67: 953.
