| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C19H17F2N3O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
c-ABL-IN-5 is a selective c-Abl inhibitor with neuroprotective effects, blood-brain barrier penetrability, metabolic stability, and favorable pharmacokinetic properties. When labeled with [18F] as compound [18F]3, it can serve as a tracer for evaluating disease-modifying efficacy by positron emission tomography (PET), supporting studies of neurodegenerative diseases such as Parkinson's disease (PD)[1]. It has a molecular formula of C19H17F2N3O and a molecular weight of 341.35 g/mol.
Physical & Chemical Properties
| CAS Number | 3056613-20-5 |
|---|---|
| Molecular Formula | C19H17F2N3O |
| Molecular Weight | 341.35 g/mol |
| SMILES | O=C(NC1=CN2C=C(C=CC2=N1)C3=CC=CC=C3CCF)[C@H]4[C@H](C4)F |
| Signaling Pathway | Protein Tyrosine Kinase/RTK |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Stéen EJL, et al. Development of 18F-Labeled PET Tracer Candidates for Imaging of the Abelson Non-receptor Tyrosine Kinase in Parkinson's Disease. J Med Chem. 2023 Sep 15...
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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