| Field | Specification |
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| Mfr No | |
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| Host | |
| Immunogen | A synthesized peptide derived from human C1QA was used as the immunogen for the C1QA antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
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| Target | |
| UniProt # |
Overview
C1QA Antibody / Complement component 1 subcomponent subunit A is a anti-C1QA Rabbit antibody Recombinant Rabbit Monoclonal clone 31C57 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Rat.
Key elements and design rationale
- Target: C1QA
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31C57, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
C1QA antibody is commonly used in immunology, inflammation, and autoimmune disease research. C1QA expression is highest in monocytes, macrophages, and dendritic cells. It functions as a pattern recognition receptor that bridges innate and adaptive immunity. By detecting C1QA, researchers can study activation of complement pathways and regulation of immune responses.
In western blot assays, C1QA antibody detects protein bands of expected size in immune cell extracts. Immunohistochemistry highlights strong expression in macrophages and tissue resident immune cells. Immunofluorescence enables visualization of C1QA in immune synapses and complement activation sites. ELISA supports quantification of circulating C1QA in biological samples.
Deficiency of C1QA is associated with autoimmune disorders such as systemic lupus erythematosus, underscoring its importance in self tolerance and immune clearance. Elevated expression of C1QA has been linked to chronic inflammation and neurodegenerative diseases, including Alzheimer disease, where complement activation contributes to pathology. By applying C1QA antibody, scientists can investigate how alterations in complement regulation affect health and disease.
C1QA antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
