| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human CABP was used as the immunogen for the CABP1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
CABP1 Antibody / Calcium binding protein 1 is a anti-CABP1 Rabbit antibody Recombinant Rabbit Monoclonal clone 31C60 supplied in Liquid format. Recommended for workflows such as Immunofluorescence (IF), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human, Mouse.
Key elements and design rationale
- Target: CABP1
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31C60, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): IF, ICC, WB
Biological background
CABP1 antibody is widely used in neuroscience and sensory biology research. CABP1 interacts with L type calcium channels and inositol 1,4,5 triphosphate receptors, tuning calcium signaling in neurons. It plays roles in learning, memory, and synaptic adaptation. In the retina, CABP1 modulates photoreceptor signaling and contributes to visual processing. By detecting CABP1, researchers can evaluate how neuronal calcium sensors shape cellular signaling.
In western blot assays, CABP1 antibody detects protein bands corresponding to expected isoforms in neural tissue. Immunohistochemistry highlights expression in hippocampus and retina, while immunofluorescence reveals subcellular localization at synapses and dendrites. These methods support detailed analysis of calcium binding proteins in neurons.
Altered CABP1 expression has been linked to neurological disorders including schizophrenia and epilepsy, where calcium signaling is disrupted. CABP1 also influences neuronal excitability and response to stress, suggesting broader roles in neuroprotection. By applying CABP1 antibody, scientists can investigate how calcium sensors contribute to brain function and disease mechanisms.
CABP1 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
