| Field | Specification |
|---|---|
| Alternative names | (4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C20H16N2O4 |
| Purity | |
| Bioactivity | Inhibitor |
| Activity | |
| Solubility | Soluble to 5 mM in DMSO |
| SMILES | |
| InChIKey | |
| Form | Yellow solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Camptothecin is a cytotoxic quinoline alkaloid that inhibits topoisomerase I, stabilizing the DNA-topoisomerase complex and preventing DNA re-ligation. This leads to DNA damage and apoptosis. In neuroscience, camptothecin is used to model DNA damage-induced neuronal death and to explore mechanisms of genomic instability in neurodegenerative diseases.
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
Risk Phrases:
- R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
- R46 - May cause heritable genetic damage
Hazard Phrases:
H302
Camptothecin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-242)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J. and Hol W.G.J. (1998) Science. 279:1504-1513.
3. Pommier Y., et al. (2003) Mutat Res. 532: 173-203.
