| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Oily material. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-methyl-2-(4-methylpent-3-enyl)-7-pentylchromen-5-ol.
- Also known as: Cannabichrome, Pentylcannabichromene, CBC
- CAS number: 20675-51-8
- Molecular formula: C21H30O2.
- Purity: >98%
- Concentration: 10 nM - 100 µM.
- Form: Oily material.
- Solubility: Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPA1, TRPM8 channels, Cannabinoid receptor 1
- Source: Synthetic
- Activity: CBC is an activator of TRPA1 with an EC50 of 90 nM and a blocker of TRPM8 with an IC50 of 40 µM1.
- Alternative names: Cannabichrome, Pentylcannabichromene, CBC
Scientific background
Cannabichromene (CBC) is a member of the cannabinoids, compounds derived from a diterpene structure origin of the marijuana plant Cannabis sativa, and particularly abundant in freshly harvested dry-type Cannabis material. These compounds have been used for over a 1000 years as medicinal agents for the relief of pain, as well as for recreational purposes1.CBC is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1) channels and enzymes of the endocannabinoid system. In addition, it also acts as a TRPM8 antagonist.CBC selectively reduces inflammation-induced hypermotility in vivo independently from cannabinoid receptors or TRPA11,2.Several studies have demonstrated that CBC exerts antimicrobial, anti-inflammatory, analgesic and antidepressant-like activity in rodents and has the ability to normalize in vivo intestinal motility in an experimental model of intestinal inflammation3.Cannabichromene potency tested induced TRPA1-mediated Ca2+ elevation showed efficacy of EC50 of 90 nM1.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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