| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (6E)-N-(4-Hydroxy-3-methoxybenzyl)-8-methyl-6-nonenamide, 8-Methyl-N-vanillyl-trans-6-nonenamide |
| Cas No. | |
| Form | Off-White Solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (20 mg/mL) and ethanol (15 mg/mL) |
| Source | Synthetic |
| Storage |
Capsaicin is a TRPV1 receptor agonist that activates non-selective cation channels in sensory neurons. It induces the release of substance P and modulates pain signaling pathways. Capsaicin has demonstrated neuroprotective effects in models of cerebral ischemia and is used to study peripheral and central nociceptive mechanisms. Its reversible inhibition of platelet aggregation also suggests vascular implications in neurodegeneration.
Classification: Toxic. May be harmful or fatal if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with shin and eyes
Risk Phrases:
R25-37/38-41-42/43
Hazard Phrases:
H301-H311-H315-H317-H318-H334-H335
Precautionary Phrases:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
Capsaicin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-322)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Story G.M., Crus-Orengo L. (2007) Am Scientist. 95(4): 326-333.
3. Vaishnava P., Wang D.H. (2003) Curr Med Chem Cadiovasc Hematol Agents. 1(2): 177-188.