| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide.
- CAS number: 138977-28-3
- Molecular formula: C19H21ClN2O2S.
- Purity: >97%
- Concentration: 0.1-100 µM.
- Form: Lyophilized Powder
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPV1, ENaCγ channels
- Source: Synthetic
- Activity: Capsazepine is a selective antagonist of the vanilloid VR1 receptor (TRPV1) with IC50 of 40 nM, and an activator of the ENaC channels.
Peptide confirmation
Confirmed by amino acid analysis and mass spectrometry
Scientific background
Capsazepine is a synthetic, competitive and selective antagonist of TRPV1 (transient receptor potential vanilloid 1)1 and an activator of amiloride-sensitive epithelial Na+ channel gamma (ENaCγ). It also inhibits K+-dependent ATP hydrolysis with no effect on Na+-ATPase2,3.Capsazepine is being used in in vitro and in vivo pharmacological studies as a standard TRPV1 competitive antagonist.Capsazepine exhibits potent inhibition of expression of the iNOS gene in LPS-stimulated murine macrophages through inactivation of NF-κB4.The amiloride-sensitive epithelial Na+ channel (ENaC) regulates Na+ homeostasis into cells and across epithelia5.TRPV1 is a member of a distinct subgroup of transient receptor potential (TRP) ion channels. These channels are highly expressed on primary nociceptors and can be activated by several different stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC6.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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