| Field | Specification |
|---|---|
| Alternative names | (4aR,10aS)-5,6-Dihydroxy-7-isopropyl-1,1-dimethyl-1,3,4,9,10,10a-hexahydro-2H-phenanthrene-4a-carboxylic acid |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C20H28O4 |
| Purity | |
| Bioactivity | Activator |
| Activity | |
| Solubility | Soluble in DMSO (50 mg/ml) |
| SMILES | |
| InChIKey | |
| Form | Off white to yellow solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Carnosic acid is a phenolic diterpene found in rosemary and sage, known for its potent antioxidant and neuroprotective properties. In neuroscience, carnosic acid has gained attention for its ability to activate the Nrf2-ARE pathway, a critical regulator of cellular defense against oxidative stress. This activation leads to the upregulation of detoxifying and antioxidant enzymes, offering protection against neuronal damage in models of Alzheimer’s, Parkinson’s, and ischemic stroke. Carnosic acid also exhibits anti-inflammatory effects by modulating microglial activation and cytokine production. Its dual action on oxidative stress and inflammation makes it a promising candidate for therapeutic development in neurodegenerative disease research.
Classification: Caution- Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Carnosic acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-362)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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2. Chen J.H., et al. Chem. (2012) Res. Toxicol 25:1893.
3. Takahashi T., et al. (2009) Biochem. Biophys. Res. Commun. 382:549.
4. Kar S., et al. (2012) Apoptosis. 17:1735.
5. Barni M.V., et al. (2012) Oncol. Rep. 27:1041.
