| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm. |
| Molecular weight | |
| Molecular formula | C20H16O5 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Carpachromene is a potent inhibitor of the α-glucosidase enzyme. It ameliorates insulin resistance in HepG2 cells by modulating the IR/IRS1/PI3k/Akt/GSK3/FoxO1 pathway[1]. It is supplied as a light yellow to yellow solid (C20H16O5, MW 336.34) at 98.84% purity.
Physical & Chemical Properties
| CAS Number | 57498-96-1 |
|---|---|
| Molecular Formula | C20H16O5 |
| Molecular Weight | 336.34 g/mol |
| Purity | 98.84% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| Structure Classification | Flavonoids Flavones |
| SMILES | OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC4=C1C=CC(C)(C)O4 |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Initial Source | Plant — Calophyllaceae Calophyllum symingtonianum M.R.Hend. & Wyatt-Sm. |
| Storage | -20°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Carpachromene (0-100 μg/mL, 48 h) is cytotoxic to HepG2, HepG2/IRM, PLC/PRF/5 and Raji cancer cell lines[1]. In HepG2/IRM cells, Carpachromene (20 μg/mL) markedly raises the protein expression ratios of IR, IRS1, PI3K, Akt, GSK3 and FoxO1[1]. Carpachromene (20 μg/mL) enhances cellular glycogen synthesis in HepG2/IRM cells[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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