| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 6,7-Diepicastanospermine, 6-Epicastanospermine, 1,6,7,8-Tetrahydroxyoctahydroindolizine, NSC 625381, (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine, (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol |
| Cas No. | |
| Form | Off white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in water (25 mg/ml) |
| Source | Synthetic |
Castanospermine is a potent inhibitor of α- and β-glucosidases, enzymes involved in glycoprotein processing. While primarily studied for its antiviral and anticancer properties, Castanospermine has gained attention in neuroscience for its potential to modulate glycosphingolipid metabolism and reduce neuroinflammation. By interfering with glycoprotein maturation, it may influence protein aggregation and lysosomal function—key factors in neurodegenerative diseases such as Gaucher and Parkinson’s. Its ability to cross the blood-brain barrier and alter glycan processing makes it a valuable tool in neurodegenerative disease models.
Details:
Classification
Not WHMIS controlled.
Hazard statement(s):
- H302 + H312 Harmful if swallowed or in contact with skin
- H332 Harmful if inhaled.
Precautionary statement(s):
- P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
- P264 Wash skin thoroughly after handling.
- P270 Do not eat, drink or smoke when using this product.
- P271 Use only outdoors or in a well-ventilated area.
- P280 Wear protective gloves/ protective clothing.
- P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
- P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
- P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
- P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
- P322 Specific measures (see supplemental first aid instructions on this label).
- P330 Rinse mouth.
- P363 Wash contaminated clothing before reuse.
- P501 Dispose of contents/ container to an approved waste disposal plant.
Castanospermine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-529)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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