| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C21H21N5O6 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CB 3705 is an inhibitor of dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). It inhibits L1210 cells and the mutant L1210 cell line (L1210:C15) with ID50 values of 4.77 μM and 408 μM, respectively[1][2]. It has a molecular formula of C21H21N5O6 and a molecular weight of 439.42 g/mol.
Physical & Chemical Properties
| CAS Number | 5854-11-5 |
|---|---|
| Molecular Formula | C21H21N5O6 |
| Molecular Weight | 439.42 g/mol |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CC3=C(NC(N)=NC3=O)C=C2)C=C1)=O |
| Signaling Pathway | Metabolic Enzyme/Protease; Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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