CBA

CBA is a selective blocker of TRPM4 channels (IC50 = 1.5 µM), with no activity at related TRP channels or other ion channels. It has demonstrated neuroprotective effects in models of glutamate-induced neuronal degeneration and experimental autoimmune encephalomyelitis, a model of multiple sclerosis. By modulating TRPM4 activity, CBA provides a valuable tool for investigating calcium-independent cation flux in neurons and glial cells, and its role in neuroinflammation and neurodegeneration. Its specificity and in vivo efficacy make it a promising candidate for therapeutic exploration in CNS disorders.

Details:

Not a hazardous substance or mixture.

CBA (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-633)

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• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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