| Field | Specification |
|---|---|
| Target | |
| Alternative names | CCR2, C-C chemokine receptor type 2, Monocyte chemoattractant protein 1 receptor, CC chemokine receptor type 2, CCR1L, CCCKR2, CD192, MCP-1-R, MCP1 RECEPTOR, CKR2B, C-C CKR-2, CC CKR 2, CD_antigen: CD192, CC-CKR-2, CCR5L, C C chemokine receptor type 2, CD192 antigen, CKR2A, Monocyte chemoattractant protein 1 receptor, CCR 2, CCR2B, C C CKR 2, CCR-2, CMKBR2, MCP 1 R, CCR2A, Chemokine CC Motif Receptor 2, Chemokine C C motif receptor 2, CCR2_HUMAN, MCP1R, CKR 2 |
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| Accession number | |
| Host | |
| Clonality | |
| Reactivity | |
| Applications | |
| Immunogen | Synthetic peptide of Human CCR2 |
| Purification | |
| Cellular localization | |
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C-C chemokine receptor type 2 (CCR2) is a G protein-coupled receptor that plays a pivotal role in regulating immune cell trafficking and neuroinflammatory responses. In the central nervous system (CNS), CCR2 is expressed on monocytes, microglia, and neurons, where it mediates the recruitment of immune cells in response to injury or disease.
CCR2 activation facilitates the infiltration of monocytes into the brain and spinal cord, contributing to both protective and pathological outcomes. In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS), CCR2 signaling influences microglial activation, cytokine release, and the clearance of neurotoxic proteins. While CCR2-mediated immune responses can support tissue repair and amyloid-beta clearance, chronic activation may exacerbate inflammation and neuronal damage.
The dual role of CCR2 in neuroprotection and neurotoxicity makes it a compelling target for therapeutic intervention. Inhibiting CCR2 signaling may reduce harmful inflammation, while enhancing its function could promote immune-mediated clearance of pathological aggregates.
As a key regulator of immune dynamics in the brain, CCR2 is a promising biomarker and therapeutic target in the development of disease-modifying treatments for neurodegenerative disorders. Its modulation offers a strategic approach to balancing immune surveillance with neuroprotection.
A 1:1000 dilution of SPC-704 was sufficient for detection of CCR2 in 15 µg of rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-704D — Size: 100 ug: CCR2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D, RRID: AB_2705951)
- SPC-704D-A390 — Size: 100 ug: CCR2 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-A390, RRID: AB_2705952)
- SPC-704D-A488 — Size: 100 ug: CCR2 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-A488, RRID: AB_2705953)
- SPC-704D-A594 — Size: 100 ug: CCR2 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-A594, RRID: AB_2705955)
- SPC-704D-APC — Size: 100 ug: CCR2 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-APC, RRID: AB_2705961)
- SPC-704D-BI — Size: 100 ug: CCR2 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-BI, RRID: AB_2705962)
- SPC-704D-FITC — Size: 100 ug: CCR2 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-FITC, RRID: AB_2705963)
- SPC-704D-HRP — Size: 100 ug: CCR2 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-HRP, RRID: AB_2705964)
- SPC-704D-PCP — Size: 100 ug: CCR2 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-PCP, RRID: AB_2705966)
- SPC-704D-RPE — Size: 100 ug: CCR2 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704D-RPE, RRID: AB_2705967)
- SPC-704S — Size: 12 ug: CCR2 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-704S, RRID: AB_2705951)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
