| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | Recombinant mouse protein (amino acids Q20-N374) was used as the immunogen for the Cd244 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
Cd244 Antibody / Natural killer cell receptor 2B4 is a anti-CD244 Rabbit antibody Polyclonal (rabbit origin) supplied in Antigen affinity purified format. Recommended for workflows such as Western blot (WB), IHC-P, Direct ELISA with listed reactivity in Mouse, Rat. Reported localization: Cell membrane.
Key elements and design rationale
- Target: CD244
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Antigen affinity purified
- Applications (as listed): WB, IHC-P, Direct ELISA
Biological background
Dysregulated CD244 signaling is linked to impaired NK function in chronic viral infection, T cell exhaustion in tumors, and altered myeloid responses. Expression level, phosphorylation status, and adaptor association serve as readouts for immune competence in immuno-oncology, vaccine studies, and autoimmunity research, making precise detection with the CD244 antibody valuable for mechanistic and translational investigations.
The CD244 antibody supports applications such as flow cytometry, immunohistochemistry, and western blot to quantify receptor abundance, track subcellular localization, and assess pathway modulation under genetic or pharmacologic perturbation. With high specificity and reproducible performance across primary cells and model systems, the CD244 antibody enables rigorous analysis of NK and T cell biology.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
