| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C20H21FN6O4S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
CDK2-IN-19 is a selective, orally active inhibitor of CDK2 (Ki 0.18 nM). It has demonstrated anticancer activity in mice bearing OVCAR3 tumors[1]. It has a molecular formula of C20H21FN6O4S and a molecular weight of 460.48 g/mol.
Physical & Chemical Properties
| Molecular Formula | C20H21FN6O4S |
|---|---|
| Molecular Weight | 460.48 g/mol |
| SMILES | FC(C=C(S(=O)(NC)=O)C=C1)=C1NC2=NC=C3C(N=C(C(N4C[C@@H](OC)[C@@H]4C)=O)C=C3)=N2.FC(C=C(S(=O)(NC)=O)C=C5)=C5NC6=NC=C7C(N=C(C(N8C[C@H](OC)[C@H]8C)=O)C=C7)=N6 |
| Signaling Pathway | Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
Ki: 0.18 nM (CDK2)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Mingshuo Zeng, et al. Discovery of Selective Tertiary Amide Inhibitors of Cyclin-Dependent Kinase 2 (CDK2). ACS Med. Chem. Lett. 2023.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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