| Field | Specification |
|---|---|
| Alternative names | Cephaloglycin |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H19N3O6S |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Cefaloglycin, also known as Cephaloglycin, is an orally active, nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity against Gram-positive cocci other than enterococci. It is also toxic to mitochondrial substrate uptake and respiration[1][2][3]. It is supplied as a white to light yellow solid (C18H19N3O6S, MW 405.42) at 96.06% purity.
Physical & Chemical Properties
| CAS Number | 3577-01-3 |
|---|---|
| Molecular Formula | C18H19N3O6S |
| Molecular Weight | 405.42 g/mol |
| Purity | 96.06% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | OC(C(N(C1=O)[C@@](SC2)([H])[C@@H]1NC([C@@H](C3=CC=CC=C3)N)=O)=C2COC(C)=O)=O |
| Signaling Pathway | Anti-infection |
| Storage | -20°C, protect from light, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
In vitro activity of Cefaclor against S. pyogenes is comparable to that of Cephaloglycin and somewhat superior to that of Cephalexin[2].
In Vivo
Respiration and uptake of succinate and ADP are determined in rabbit renal cortical mitochondria that were exposed to 300 to 3,000 μg of Cefaloglycin (Cephaloglycin) per mL for 2 to 6 h and then washed free of the antibiotic. Both respiration and succinate uptake are irreversibly reduced by Cefaloglycin (Cephaloglycin). The in vitro injury caused by Cefaloglycin to mitochondrial substrate uptake and respiration develops in a time- and concentration-dependent manner[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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