| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin |
| Cas No. | |
| Form | Red Powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 45 mg/ml DMSO, 30 mg/ml Ethanol |
| Source | Synthetic |
| Storage |
Celastrol is a potent antioxidant and anti-inflammatory compound that inhibits NFκB and proteasome activity. It induces heat shock response and cytoprotection. In neurodegenerative disease research, Celastrol is investigated for its ability to reduce oxidative stress, modulate inflammation, and enhance cellular resilience in models of Alzheimer's and Parkinson's disease.
Classification: Toxic- Toxic Material Causing Immediate and Serious Toxic Effects
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
H301 – Toxic if swallowed
Precautionary Statements:
P301 + P31 – If Swallowed, immediately call a POISON CENTER or doctor.
Celastrol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-333)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Westerheide S.D., et al. (2004) J. Biol. Chem. 279: 56053.
3. Yang H., et al. (2006) Cancer Res. 66: 4758.
